Bisque deconvolution of bulk data using an `screference`

Usage

bisque_deconvolute(bulk_data, scref)

Arguments

bulk_data: a matrix of bulk RNA-seq data with rows representing genes and columns representing samples.
scref: an object of class `screference`

Value

a tibble containing the fraction of each cell type in each bulk sample.

Note

Reference: Jew, B., Alvarez, M., Rahmani, E. et al. Accurate estimation of cell composition in bulk expression through robust integration of single-cell information. Nat Commun 11, 1971 (2020). https://doi.org/10.1038/s41467-020-15816-6 See also: https://github.com/cozygene/bisque